Saint Petersburg State University

Abstract. This work is devoted to development of mathematical model, describing processes of Th and B lymphocyte proliferation and differentiation, as well as  IFN-γ, IL-2, IL-4 and IL-21 cytokine secretion. New approaches are suggested, allowing more accurate modelling. Special attention paid to Th17 lymphocyte impact to effect of plasma cells and IgM and IgG antibody level increasing.