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Volume 10   Issue 2   Year 2015
Mathematical Model of the Humoral Immune Response: Focusing On Th17 Autoimmunity

Kuznetsov S.R.

Saint Petersburg State University

Abstract. This work is devoted to development of mathematical model, describing processes of Th and B lymphocyte proliferation and differentiation, as well as  IFN-γ, IL-2, IL-4 and IL-21 cytokine secretion. New approaches are suggested, allowing more accurate modelling. Special attention paid to Th17 lymphocyte impact to effect of plasma cells and IgM and IgG antibody level increasing.

Key words: systems immunology, lymphocyte, cytokine network, IgM, IgG, IL-17.
Table of Contents Original Article
Math. Biol. Bioinf.
doi: 10.17537/2015.10.455
published in English

Abstract (eng.)
Abstract (rus.)
Full text (eng., pdf)


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