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Volume 14   Issue 1   Year 2019
Yin and Yang of Pluripotency: Results of Analysis of Genes Overexpressed In Tumor-Initiating Cells of Krebs-2 Ascites Carcinoma

Efremov Y.R.1,2, Proskurina A.S.1, Potter E.A.1, Dolgova E.V.1, Efremova O.V.2, Kolchanov N.A.1, Bogachev S.S.1

1Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
2Novosibirsk State University, Novosibirsk, Russia

Abstract. Functional analysis of 167 genes overexpressed in Krebs-2 tumor initiating cells was performed. Genes were assigned to the three functional groups that determine the malignant phenotype of cancer cells. These groups represent the following features of tumor cells: proliferative self-sufficiency, invasive growth and metastasis, and multiple drug resistance. Malignancy of cancer stem cells was found to be provided by the same genes that provide the stemness of normal pluri-/multipotent stem cells. These results suggest that the malignancy is just the ability to maintain the stem cell specific genes expression profile, and, as a consequence, the stemness itself regardless of the controlling effect of stem niches.

Key words: malignancy, cancer stem cells, pluripotency, stem cell niche, genes-markers of stemness.

Table of Contents Original Article
Math. Biol. Bioinf.
doi: 10.17537/2019.14.160
published in Russian

Abstract (rus.)
Abstract (eng.)
Full text (rus., pdf)


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