Russian version English version
Volume 8   Issue 1   Year 2013
Computer-Aided Design of Novel HIV-1 Entry Inhibitors Based on Glycosphingolipids

Andrianov A.M., Kornoushenko Yu.V., Kashyn I.A., Tuzikov A.V.

Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, 220141, Republic of Belarus
United Institute of Informatics Problems, National Academy of Sciences of Belarus, Minsk 220012, Republic of Belarus
 
 
Abstract. Twelve water-soluble analogs of glycosphingolipid β-galactosylceramide, which present potential anti-HIV agents able to specifically and effectively interact with the conserved structural motifs of the HIV-1 V3 loop containing the envelope gp120 residues critical for cell tropism, were designed by computer modeling. The compounds obtained were shown to exhibit the promising basic structures for the development of novel, potent and broad antiviral drugs.
 
Key words: HIV-1, gp120 protein, V3 loop, glycosphingolipids, molecular modeling, anti-HIV agents. 
Table of Contents Original Article
Math. Biol. Bioinf.
2013;8(1):258-275
doi: 10.17537/2013.8.258
published in Russian

Abstract (rus.)
Abstract (eng.)
Full text (rus., pdf)
References

 

  Copyright IMPB RAS © 2005-2024