Estimating the Time of Crossing a High, Long and Arbitrary Bumpy Free Energy Barrier
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region142290, Russia
Abstract. This communication presents a simple but rather general analytical estimate of the characteristic time of crossing a long, high and arbitrary bumpy free energy barrier in a course of sequential chemical, biochemical or physical reaction.
Key words: free energy of the barrier, time of crossing the barrier, polymerization, one-dimensional diffusion, quasistationary approximation, generalized quasistationary approximation, secondary structure formation, population of intermediate states.