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Volume 9   Issue 2   Year 2014
Identification of Gene Markers for Aggressive Forms of Low-Grade Glioma Using TCGA Expression Data

Ivanisenko N.V., Gubanova N.V., Kolchanov N.A., Ivanisenko V.A.

Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia
Novosibirsk State University, Novosibirsk, Russia

Abstract. Low-grade glioma is a group of tumors of central nervous system. Unlike other malignant subtypes such as glioblastoma multiforme, low-grade gliomas have a lower mortality. However, after initial treatment in about 40% of low-grade gliomas new tumor events are observed. In this study identification of new genes responsible for the aggressive phenotype of tumors was carried out using RNA-seq data from the The Cancer Genome Atlas (TCGA) database. It was found that 85 genes with affected expression levels were associated with new tumors after initial treatment of low-grade glioma. 
Key words: low-grade glioma, RNA-seq, new tumor event, TCGA. 
Table of Contents Original Article
Math. Biol. Bioinf.
doi: 10.17537/2014.9.527
published in Russian

Abstract (rus.)
Abstract (eng.)
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