PPROMEDIA – Database of Chemical Substances the Potential Biomarkers of Diseases with the Meaning in Noninvasive Diagnostics
Saik O.V., Moshkin M.P., Baldin M.N., Grouznov V.M., Kozlov V.A., Samorokov S.N., Demenkov P.S., Ivanisenko V.A., Kolchanov N.A.
Institute of Cytology and Genetics, SB RAS, Novosibirsk, 630090, Russia
A.A. Trofimuk Institute of Petroleum Geology and Geophysics, SB RAS, Novosibirsk, 630090, Russia
Institute of Clinical Immunology, SB RAMS, Novosibirsk, 630047, Russia
Sobolev Institute of Mathematics, SB RAS, Novosibirsk, 630090, Russia
Novosibirsk State University, Novosibirsk, 630090, Russia
Abstract. There is a potential use of volatile biomarkers for noninvasive diagnostics in medicine. Creating a common information resource based on the integrated data from different sources of chemical compounds with the potential diagnostic meaning facilitates the planning of experiments on noninvasive diagnostics. The database containing information on potential biomarkers of diseases at the level of metabolites, enzymes, transcription factors that allows planning the experiments on noninvasive diagnostics of diseases was developed. Using database ProMeDiA on the example of aspergillosis infection caused by Aspergillus fumigatus, was undertaken the analysis of volatile compounds involved in the reactions regulated by human enzymes, associated with aspergillosis, and by A. fumigatus enzymes. The potential volatile biomarkers of aspergillosis infection were proposed. On the example of metabolism changes in rheumatoid arthritis the possibility of using database ProMeDiA for metabolic networks reconstruction, which allows identifying potential biomarkers of diseases, was demonstrated.
Key words: databases, noninvasive diagnostics, volatile biomarkers of diseases, metabolites, proteins.
