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| Volume 11 Issue 2 Year 2016 | ||
Stoichiometric Modeling of Oxygen Transportation through the Surface of Isolated Perfused Rat Liver
Shadrin K.V., Pakhomova V.G., Rupenko A.P., Kryukova Ξ.V., Khlebopros R.G. Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of Science Abstract. Stoichiometric modeling allows analyzing the features of metabolism both the cell populations and the holistic isolated organs. In this paper, one of the stoichiometric modeling methods, Flux Balance Analysis, was used to investigate the mechanisms of oxygen transportation through the surface of the isolated perfused rat liver at various oxygenation conditions. It is shown that the oxygen intake through the surface of the isolated perfused liver is associated with energy consumption.
Key words: stoichiometric modeling, the oxygen transportation, perfusion, hypoxia.
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Table of Contents
Original Article
Math. Biol. Bioinf. 2016;11(2):263-277 doi: 10.17537/2016.11.263 published in Russian Abstract (rus.) Abstract (eng.) Full text (rus., pdf) References
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