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Volume 12   Issue 2   Year 2017
Structural-Statistical Properties of the Flavivirus Genomes

Tyulko Zh.S., Kutyrkin V.A., Chaley M.B.

Omsk State Medical University of Ministry of Healthcare of the Russian Federation, Omsk, 644099, Russia
Moscow State Technical University n.a. N.E. Bauman, Moscow, 107005, Russia
Institute of Mathematical Problems of Biology RAS – the Branch of Keldysh Institute of Applied Mathematics of Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia

Abstract. Essential structural-statistical properties of coding regions in the genomes of flaviviruses are investigated on base of the Spectral-statistical approach. Both full-length polyprotein coding sequences and their separated structural segments are analyzed. On the whole, structural-statistical properties of the flavivirus genome sequences are shown to be similar to the properties of 3-regularity and latent triplet profile periodicity revealed earlier in the coding regions of prokaryotic and eukaryotic genomes. However, two-level organization of coding is not occurred in discrete segments coding for structural proteins in the flavivirus genomes and property of sequence homogeneity is manifested in significant part of such the segments. These coding sequence particularities are explained by simple structure and high mutation rate of the flavivirus genomes.

Key words: flavivirus genome, prokaryotic genome, eukaryotic genome, spectral-statistical approach, latent profile periodicity, property of 3-regularity.

Table of Contents Original Article
Math. Biol. Bioinf.
doi: 10.17537/2017.12.343
published in Russian

Abstract (rus.)
Abstract (eng.)
Full text (rus., pdf)


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