Commentary on the Work of Jimak S.S. et al. “Mathematical Modeling of Open States in Double Stranded DNA Molecule Depending on 2H/1H Ratio”
Institute of Mathematical Biology RAS, M.V. Keldysh Institute of Applied Mathematics of RAS, Pushchino, Russia
Abstract. The article is analyzed Jimak S.S. et al. “Mathematical modeling of open state accounting as a function of 2H/1H ratio in a double-stranded DNA molecule”, appeared in “Mathematical Biology and Bioinformatics”. The values of H-bond energies used in the simulation as a parameter are estimated. A new mechanism for the effect of DNA deuteration on biological function of DNA described by authors is proposed.
Key words: open state of DNA, DNA deuteration, angular mechanical model.