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Volume 2   Issue 1   Year 2007
A Stochastic Model of the Intracellular Dynamics of the Multicopy Bacterial Plasmids Subject to Control of Replication

Shuvaev A.N., Brilkov A.V.

Institute of Biophysics SB RAS, Krasnoyarsk, 660036, Russia
Siberian Federal University, Krasnoyarsk, 660041, Russia

Abstract. The dynamics of the bacterial plasmids was investigated in case of small shifts from the stationary state. By shifts we understand the alteration of the plasmid copy number from the stationary value. The Fokker-Planck approximation for one-step processes was used here. The dynamics was found to happen in Ornstein-Uhlenbeck form. The research data allows us to predetermine that hyperbolic inhibition mechanism describes the plasmid replication control process in a good way.

Key words: plasmids, replication control, one-step process, Ornstein-Uhlenbeck process, Fokker-Planck equation.



Table of Contents Original Article
Math. Biol. Bioinf.
doi: 10.17537/2007.2.66
published in Russian

Abstract (rus.)
Abstract (eng.)
Full text (rus., pdf)


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