Reduction of the Model of CD95-induced Apoptosis

Mathematical Biology & Bioinformatics. 2012;7(1):139-151.

doi: 10.17537/2012.7.139.

1. MacFarlane M, Williams AC. Apoptosis and disease: a life or death decision. EMBO Rep. 2004;5:674-678. doi: 10.1038/sj.embor.7400191
2. Krammer PH, Rüdiger A, Lavrik IN. Life and death in peripheral T cells. Nature Reviews Immunology. 2007;7:532-542. doi: 10.1038/nri2115
3. Bentele M, Lavrik I, Ulrich M, Stößer S, Heermann DW, Kalthoff H, Krammer PH, Eils R. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J. Cell Biol. 2004;166(6):839-851.
4. Gorban AN, Radulescu O, Zinovyev AY. Asymptotology of Chemical Reaction Networks. Chem. Eng. Sci. 2009;65:2310-2324.
5. Choi J, Yang KW, Lee TY, Lee SY. New time-scale criteria for model simplification of bio-reaction systems. BMC Bioinformatics. 2008;9. Article number 338. doi: 10.1186/1471-2105-9-338
6. Quaiser T, Dittrich A, Schaper F, Mönnigmann M. A simple workflow for biologically inspired model reduction – application to early JAK-STAT signaling. BMC Systems Biology. 2011;5. Article number 30. doi: 10.1186/1752-0509-5-30
7. Schilling M, Maiwald T, Hengl S, Winter D, Kreutz C, Kolch W, Lehmann WD, Timmer J, Klingmüller U. Theoretical and experimental analysis links isoform-specific ERK signaling to cell fate decisions. Molecular Systems Biology. 2009;5. Article number 334. doi: 10.1038/msb.2009.91