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Volume 5   Issue 2   Year 2010
Development of Mathematical Methods and Software for Protein's Functional Sites Detection

Shutova I.V., Golubovich V.P.

Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus

Abstract. The program for analysis of protein's surfaces with the purpose of functional site detection has been designed. The program allows building the molecular protein's surfaces, detecting the pockets, canals and cavities and carrying out the analysis of hydrophobic areas and charge distribution on the surfaces. Using this program one of functional sites of human G-CSF has been defined and its low-molecular functional analog has been forecasted.

Key words: protein's functional site, structural features of protein's surface, cavities, canals, pockets.

Table of Contents Original Article
Math. Biol. Bioinf.
doi: 10.17537/2010.5.162
published in Russian

Abstract (rus.)
Abstract (eng.)
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