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Volume 6   Issue 2   Year 2011
Analysis of the intracellular mechanisms contribution to the action potential generation changes in excitable cell models

Vasilyeva A.D., Solovyova O.E.

Institute of Immunology and Physiology of the RUS, Ekaterinburg, 620049, Russia
Institute of Mathematics and Computer Science, Ural Federal University named after the first President of Russia B.N.Yeltsin, Ekaterinburg, 620083, Russia

Abstract. Transmembrane ion channels and exchangers are involved in forming of the excitable cell action potential (AP). When changing conditions of functioning of the cells  an alters appear in the interaction of mechanisms to form AP reflecting a variation of AP shape and duration. Comparative evaluation of the effect of different cellular mechanisms on AP generation in the mathematical models became possible due to development of special methods. Using these methods we have proposed an approach that allows to analyze the causes of AP shape changes in excitable cell model as a result of various influences.

Key words: action potentials, electrophysiological model, leading potential analysis, difference – current integral method.


Table of Contents Original Article
Math. Biol. Bioinf.
doi: 10.17537/2011.6.200
published in Russian

Abstract (rus.)
Abstract (eng.)
Full text (rus., pdf)


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