Russian version English version
Volume 13   Issue 1   Year 2018
Vladimir D. Gusev, Liubov A. Miroshnichenko, Tatiana N. Titkova, Yuri P. Dzhioev, Irina V. Kozlova, A.I. Paramonov

Structured RNA Markers for Genotyping of Tick-Borne Encephalitis Virus

Mathematical Biology & Bioinformatics. 2018;13(1):13-37.

doi: 10.17537/2018.13.13.



  1. Zil'ber L.A. Epidemicheskie entsefality (Epidemic Encephalitis). Moscow, Medgiz; 1945. 255 p. (in Russ.).
  2. Votiakov V.I., Zlobin V.I., Mishaeva N.P. Kleshchevye entsefality Evrazii (Tick-borne encephalitis of Eurasia). Novosibirsk, Nauka; 2002. 438 p. (in Russ.).
  3. Virus Taxonomy: VIIIth Report of the ICTV. Eds. Fauquet C.M., Mayo M.A., Maniloff J., Desselberger U., Ball L.A. London: Elsevier/Academic Press; 2005. 1162 p.
  4. Pletnev A.G., Yamshchikov V.F., Blinov V.M. Nucleotide sequence of the genome and complete amino acid sequence of the polyprotein of the tick-borne encephalitis virus. Virology. 1990;174(1):250-263. doi: 10.1016/0042-6822(90)90073-Z
  5. Mandl C.W., Heinz F.X., Stöckl E., Kunz C. Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses. Virology. 1989;173:291-301. doi: 10.1016/0042-6822(89)90246-8
  6. Pletnev A.G. Structure, organization and detection of the tick-borne encephalitis virus genome: PhD Thesis (Chemical Sciences). Moscow; 1990. 48 p. (in Russ.).
  7. Belikov S.I., Gusev V.D., Miroshnichenko L.A., Titkova T.N. In: Mathematical Biology and Bioinformatics (ICMBB12): Proceedings of the IV International Conference (October 14-19, 2012, Pushchino, Russia). 2012. P. 52-53 (in Russ.).
  8. Demina T.V. Voprosy genotipirovaniia i analiz geneticheskoi variabel'nosti virusa kleshchevogo entsefalita (Genotyping and analysis of genetic variability of tick-borne encephalitis virus): PhD Thesis (Biological Sciences, 03.02.02 – Virology). Irkutsk; 2013. 248 p. (in Russ.).
  9. Ecker M., Allison S.L.,Meixner T., Heinz F.X. Sequence analysis and genetic classification of tick-borne encephalitis viruses from Europe and Asia. Journal of general virology. 1999;80(1):179-85. doi: 10.1099/0022-1317-80-1-179
  10. Demina T.V., Zlobin V.I., Verxozina M.M., Ochirova L.A., Batomunkuev A.S., Chxenkeli V.A. Analysis of the tick-borne encephalitis virus coding sequences. Live and Biocose Systems. 2014;9. (accessed 26 February 2018) (in Russ.).
  11. Demina T.V., Dzhioev Iu.P., Kozlova I.V., Verkhozina M.M., Tkachev S.E., Doroshchenko E.K., Lisak O.V., Paramonov A.I., Zlobin V.I. Genotypes 4 and 5 of the tick-borne encephalitis virus: features of the genome structure and possible scenario for its formation. Voprosy Virusologii (Problems of Virology). 2012;4:13-19.(in Russ.).
  12. Grard G., Moureau G., Charrel R.N., Lemasson J.-J., Gonzalez J.-P., Gallian P., Gritsun T.S., Holmes E.C., Gould E.A., de Lamballerie X. Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenic determinants and taxonomy. Virology. 2007;361:80-92. doi: 10.1016/j.virol.2006.09.015
  13. Kerschner J.H., Vonrdam A.V., Monath T.P., Trent D.W. Genetic and epidemiological studies of Dengue type 2 viruses by hybridization using synthetic deoxyoligonucleotides as probes. J. Gen. Virol. 1986;67:2645-2661. doi: 10.1099/0022-1317-67-12-2645
  14. Shamanin V.A., Pletnev A.G., Rubin S.G., Zlobin V.I. Differentiation of strains of tick-borne encephalitis virus by means of RNA-DNA hybridization. J. Gen. Virol. 1990;71:1505-1515. doi: 10.1099/0022-1317-71-7-1505
  15. Zlobin V., Gazo M.Kh., Belikov S., Dzhioev Yu.P., Demina T., Verkhozina M.M., Kozlova I.V., Adelshin R., Doroshchenko Ye.K. Molecular probes for genetic typing of tick-borne encephalitis virus. Voprosy Virusologii (Problems of Virology). 2001;4:43-47 (in Russ.).
  16. Shamanin V.A. Detection of strains of tick-borne encephalitis virus by molecular hybridization of nucleic acids: PhD Thesis (Biological Sciences). Novosibirsk; 1990. 24 p. (in Russ.).
  17. Gusev V.D., Kulichkov V.A., Chupakhina O.M. Molekuliarnaia biologiia (Molecular Biology). 1991;25(3):825-833 (in Russ.).
  18. Gusev V.D., Miroshnichenko L.A., Chuzhanova N.A. In: Classification, Forecasting, Data Mining. Vol. 8 Sofia: Institute for Information Theories and Applications; 2009. (Information Science & Computing. International Book Series). P. 117−123 (in Russ.).
  19. Gusev V.D., Miroshnichenko L.A. Detection of the combined structures in DNA sequences. In: Proceedings of the 13th All-Russian Conference “Mathematical methods of pattern recognition”. Zelenogorsk (Leningrad Region, September 30 – October 6, 2007). Moscow, Max Press; 2007. P. 473-476 (in Russ.).
  20. Jeffreys A., Wilson V., Thein S. Individual-specific “fingerprints” of human DNA. Nature. 1985;316(6023):76-79. doi: 10.1038/316076a0
  21. Karan' L.S., Pogodina V.V., Bochkova N.G. Malenko G.V., Levina L.S., Frolova T.V., Miazin A.E., Platonov A.E. In: Genodiagnosis of infectious diseases: Proceedings of the 5th All-Russian Scientific and Practical Conference. Vol. 2. Part 6: Genodiagnostics of especially dangerous infections. 2004:177-179 (in Russ.).
  22. Lempel A., Ziv J. On the complexity of finite sequences. IEEE Trans. Inform. Theory. 1976:IT-22(1):75-81. doi: 10.1109/TIT.1976.1055501
  23. Solovyev V.V., Korolev S.V., Tumanyan V.G., Lim H.A. A new approach to classification of DNA regions based on fractal representation of functionally similar sequences. Proc. Natl. Acad. Sci. of USSR (Biochemistry). 1991;319(6):1496-1500 (in Russ.).
  24. Jeffrey H.J. Chaos game representation of gene structure. Nucl. Acids Res. 1990;18:2163-2170. doi: 10.1093/nar/18.8.2163
Table of Contents Original Article
Math. Biol. Bioinf.
doi: 10.17537/2018.13.13
published in Russian

Abstract (rus.)
Abstract (eng.)
Full text (rus., pdf)


  Copyright IMPB RAS © 2005-2024