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Volume 15   Issue 2   Year 2020
Method of Constructing an Asymmetric Human Bronchial Tree in Normal and Pathological Cases

Medvedev A.E.

Khristianovich Institute of Theoretical and Applied Mechanics SB RAS, Novosibirsk, Russia
Novosibirsk State University, Novosibirsk, Russia
 
Abstract. The goal of the study is the analytical design of the full asymmetric human bronchial tree (irregular dichotomy) for healthy patients and patients with obstructive pulmonary diseases. For this purpose, the author has derived the special analytical formulas. All surfaces of the bronchial tree are matched with the second-order smoothness (there are no acute angles or ribs). The geometric characteristics of the human bronchial tree in the pathological case are modeled by a “starry” shape of the inner structure of the bronchus; a level of the pathology is defined by two parameters: bronchus constriction level and level of distortion of the cylindrical shape of the bronchus. Closed analytical formulas allow a researcher to construct the human bronchial tree of an arbitrary complexity (up to alveoli); moreover, the parametric dependences make it possible to specify any desirable level of airway obstruction. 
 

Key words: bronchial tree, simulation, human lungs, respiratory system, bifurcation, lung disease. 

Table of Contents Original Article
Math. Biol. Bioinf.
2020;15(2):148-157
doi: 10.17537/2020.15.148
published in English

Abstract (eng.)
Abstract (rus.)
Full text (eng., pdf)
References Translation into Russian
Math. Biol. Bioinf.
2020, 15(Suppl):t21-t31
doi: 10.17537/2020.15.t21

Full text (rus., pdf)

 

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